Microbiological analysis of wastewater can play a strategic role in the prospective and regular monitoring of the territory to respond to the health crisis linked to the COVID-19 outbreak and other viruses. Controlling the possible outbreak of SARS-CoV-2 is a health issue. A system integrating SARS-CoV-2 and other viruses in urban wastewater would strengthen epidemiological surveillance capabilities by providing ad hoc information for early warning as close to communities. The aim of the project (October 2020-September 2023) is to monitor the community circulation of SARS-CoV-2 and other epidemic viruses through the prospective analysis of wastewater treatment plants in Auvergne to inform regional stakeholders. The operational objectives are: develop a SARS-CoV-2 RNA capture/hybridation method; extend monitoring to wastewater treatment plants in 4 departments of Auvergne; compare viruses detected in wastewater to those reported in patients. The expected results are: information provided to public decision-makers and socio-economic actors, the strengthening of local operational programmes and the structuring of the Clermont university site. Project support: Regional Health Agency, delegates and water treatment plant operators, Association Syndicale Authorised Limagne Noire, Clermont Auvergne Innovation.