The increase in the number and types of antibiotic resistance (AMR) is one of the greatest public health challenges worldwide. Antibiotics pose an environmental problem for being indirect and uncontrolled routes of exposure. Livestock farms, the rural economic engine of the POCTEFA territory, are the largest emitters of antibiotics to the environment and the main responsible for the indirect exposures, due to their presence in meats, slurry and their direct emission to fresh waters. To recover the quality of the waters and ecosystems of the POCTEFA territory, a collaborative and multidisciplinary approach is needed to guarantee and improve environmental, animal and human health. The general objective of OUTBIOTICS is to eliminate or significantly reduce antibiotics in waters of the POCTEFA territory by developing innovative technologies based on nano-micro inert materials for the prevention of antibiotics emissions and water decontamination. It is also intended to raise awareness of the importance of AMR, to diagnose the state of the waters of the territory, to apply new tools for replacing antibiotics (in animal production) and for water remediation, and finally to propose feasibility, transferability and integral management plans for the territory for these emerging pollutants.