The main target of this project is the creation of a scientific network of excellence dedicated to prion diseases. These neurodegenerative diseases affect the animals and human populations of the franco-spanish border area and there is no treatment or ante-mortem diagnostic test reliable for detection. The transmission of animal prions to humans (zoonoses) by the consumption of contaminated food remains a major concern for the European health authorities. Our project aims to coordinate and combine the skills of Research Centres, large hospital centres and private partners of the cross-border region so: - to better protect people from the risks associated with prion diseases (zoonoses and iatrogenic transmission). - to develop therapeutic approaches and innovative diagnostic tools for patients. - to ensure the sustainability of the specific production chains in the crossborder region in the face of the risk of prion agents in the agri-food field., - to inform policymakers and professionals in charge of Public and Animal Health, skateholders in the production chains and the general public of the solutions and innovations in the field of the prevention of risks associated with these diseases.