The development of sustainable tourism, integrated with soft mobility and intermodality, represents a prospect of socio-economic growth for the entire cross-border area. Protected natural areas, together with cultural and archaeological heritage, are the added value of the regions of Tuscany, Liguria, PACA, Corsica and Sardinia. The shared challenge consists in identifying and managing an integrated system of sustainable tourist routes promoting cycling and hiking throughout all partner areas without interruptions. The general objective is to increase the number of tourists in the cross-border area all year long, through a joint management plan of sustainable tourist routes. This project will identify the itinerary (feasibility study), standards (technical documents), joint promotion actions and unitary management tools (agreements, integrated plans and permanent round tables). The expected changes are greater collaboration between public administrations, greater tourist diversification, integration of tourism and intermodal supplies, greater involvement of SMEs in the tourism sector, greater cooperation between local governments and SMEs, the birth of domestic and cross-border business networks for service provision and management and greater sharing of thematic routes by locals and tourists through ICT tools. A joint cross-border approach can achieve better results. Public administrations, parks, cultural heritage, SMEs, tourists and locals will be the primary beneficiaries. The innovative aspects will concern joint cross-border management and the services and promotion sector with extensive use of ICT technologies.