The Key problem, addressed by “CREAzone 2.0” is disproportionately high unemployment rate, especially among youth, arising from the disparities between Programme regions and capital cities. In order to tackle this Key problem we are going to promote youth entrepreneurship and foster young persons exploit an unleashed local potential for international business growth by reinventing business models in traditional sectors and merging those with innovative elements of knowledge economy. We strongly believe that by changing a “status quo” in traditional sectors young entrepreneurs will be able to establish feasible business companies and create significant employment opportunities both for themselves and for other people in the region while still living in the region. The overall objective of the “CREAzone 2.0” project is to create new promising businesses by combining innovative knowledge economy driven ideas with business models in traditional industries thus contributing to the long-term and sustainable rise of employment in the Lithuanian-Latvian cross-border region. By implementing the project we will create new business opportunities in traditional industries in the Lithuanian-Latvian cross-border region by knowledge economy driven promotion of youth entrepreneurship in accordance with “CREAzone” methodology as well as build an alliance of stakeholders, who are determined to create long-term collaboration on promotion of youth entrepreneurship. The project “CREAzone 2.0” is based on the methodology that was applied, tested and improved during the “CREAzone 1.0” project in 2012-2013. However, significant innovative changes has been made to the project methodology to adapt it to addressing Key Problem on an international scale.