All project activities are focused on the main subject of fighting infections caused by particularly resistant microorganisms (BRMO), as well as the avoidance of antimicrobial resistance in humans and animals and the associated risks for the patient and public health. In order to maintain or improve the current situation of health and healthcare in the German-Dutch border area, German and Dutch health and knowledge institutions from the whole program area (4 Euregios) over the project duration (4 years) have to cooperate intensely across the border and across sectors (human and veterinary).