LIMMUNOTERAPIA BASED ON IMMUNOLOGICAL CHECKPOINT INHIBITORS REPRESENTS THE EMERGING SECTOR OF CANCER THERAPY, WITH AN EXPONENTIAL GROWTH MARKET. IN PARTICULAR, MONOCLONAL ANTIBODIES (MABS) CAPABLE OF INHIBITING CTLA-4, PD-1 AND PD-L1, APPROVED FOR SEVERAL SOLID TUMOURS AND HODGKIN’S LYMPHOMA, ARE ABLE TO REACTIVATE A GENERALISED ANTI-CANCER IMMUNE RESPONSE, PROVIDING FOR THE FIRST TIME A THERAPEUTIC AARMA TO PATIENTS WITH ADVANCED TUMOURS WITH REDUCED LIFE PERSPECTIVE. DESPITE LENTUSIASMO FOR THE RESULTS ACHIEVED SO FAR, MABS EFFICACY FOR IMMUNOTHERAPY APPROVED TO DATE IS LIMITED TO A PORTION OF TUMOURS (10-30 % OF CASES), AND IS FREQUENTLY ASSOCIATED WITH ALLÂINSORGERE OF AUTOIMMUNE ADVERSE EVENTS. THEREFORE, A LARGE PROPORTION OF TREATED PATIENTS (APPROXIMATELY 15 %) SHOULD DISCONTINUE DRUG TREATMENT DUE TO UNCURABLE ADVERSE REACTIONS. FINALLY, MANY PATIENTS ARE NOT ELIGIBLE FOR THESE TREATMENTS AT