A) Presentation of a summary of the technical content of the grant application. One of the most important tasks of medical and clinical research is to improve the effectiveness of cancer treatment, as cancer diagnoses and cancer-related deaths are growing rapidly year after year. According to World Health Organisation (WHO) statistics, in 2012 the number of cancer cases worldwide increased by 14 million in a year, which is expected to rise to 22 million a year over the next two decades. Over the same period, cancer deaths are projected to increase from 8.2 million to 13 million per year. There are three important forms of treatment: surgery, radiation therapy and chemotherapy, which are used by doctors in the fight against more than 100 types of cancer. This application is about stereotactic radiological surgery (Stereotactic Radiosurgery-SRS), a type of radiation therapy. Available radiosurgical methods and the boundaries of technology are the biggest challenge for doctors, which makes many patients unable to deal with them properly. High-level research is key to the development of this area, which contributes to the treatment of patients around the world. Our goal is to pursue a research that develops stereotactical radiation surgery to a higher level. Stereotactic radiation surgery The options available for the treatment of cancer are surgery, various forms of radiation therapy and chemotherapy. Stereotactic Radiosurgery (SRS) is a form of external irradiation that uses 3D target setting to position multiple precisely collimated beams. Beams intersect at the focal point, which allows a precisely targeted high dose of radiation to be delivered to the cancer cells so that they are exposed to minimal doses of surrounding healthy cells. For small tumours (1 cm³ — 35 cm³) and more tumours, SRS has proven advantages over other types of radiation therapy such as Conventional Radiation Therapy (RT), 3D Conformal Radiation Therapy (CRT), Intensity Modulated Radiation Therapy (RT), Intensity Modulated Radiaton Therapy (IMRT), ARC Therapy (Tomotherapy) and Brachytherapy. SRS treatment consists of a single irradiation, while other types of radiation therapy require a series of 4-6 weeks of treatment of 25-40 parts. Our goal is to carry out industrial research that enables continuous and dynamic treatment with real-time visualisation, significantly reducing the time needed for treatment, while improving the effectiveness and availability of the treatment. The boundaries of current technologies The current SRS technologies are based on three types of radiation sources: heavy particle accelerator (proton therapy), electron accelerator (LINAC) emitting gamma photons, and gamma ray system (gammakés) using radioactive isotopes. Accelerator-based systems can only emit a single beam, accelerating a particular charged particle such as the proton to high energy. However, due to a single beam, they can only apply a limited number of irradiation angles. The ability to have a large number of irradiation angles is essential for safe radiation surgery, as this property allows the transfer of high doses of radiation directly to the tumor while providing a minimum dose of surrounding healthy tissues. We see gamma knife technology as the only way to do this is because cobalt-60 radioactive isotope-based systems have a higher number of angles of entry. Cobalt-60 isotope based systems use gamma radiation generated during the decomposition of radioactive isotopes. Gamma radiation consists of photon rays produced by isotropic decay in several separate cobalt-60 sources. The protection of undamaged tissues can also be enhanced in the case of the other two technologies, but they are at a high disadvantage. Particle beam therapeutic devices protect healthy tissues in the path of the radiation by adjusting the location of the so-called Bragg tip (which depends on the energy of the particle) to the position of the tumor. One of the biggest drawbacks of the technology is its very high unit cost due to the use of the necessary accelerators. The medical linear accelerator (LINAC) emits a well-defined X-ray photon mucus with a uniform intensity in the energy range between 4 MeV and 25 MeV. A well-designed LINAC produces a sufficiently small isocentric sphere (1 mm diameter) to be applied to radiation surgery. LINAC boundaries are reflected in the number of irradiation angles and the inflexibility of the focus point size. Cobalt-60 radioactive isotope-based systems have a higher number of entry angles, but they also have technological boundaries. Currently, they can only be used for in-cranial treatment, as the remaining parts of the body cannot be maintained. The most important components of the SRS developments are: the bet