The Hygiene Business Project (HygLi) supports the smart specialisation of the Satakunta region in the field of indoor hygiene and related resource-wise building technology. The aim is to identify the business potential related to the hygiene of the whole region’s indoor environment and to create a strong basis for clustering of the sector and for Satakunta’s specialisation as an innovation hub in the sector. In the current economic and industrial transition, hygienic products and services, as well as their resource- and material-wise implementation, are a new opportunity for many operators. The HygLi project will create new Living Lab innovation platforms for piloting, for example, the public buildings of the city of Rauma and the upcoming campuses of Satakunta University of Applied Sciences. The project develops the infrastructure of regional R & D activities, one of the priorities of the Satakunta Provincial Programme, by networking research from universities, enterprises and the public sector. The project supports innovation cooperation, innovation openings and networking among the operators in the region through workshops and trainings, as well as the concrete Living Lab innovation platforms mentioned above. The innovation opening in one project is a new building engineering design guidelines for the implementation of a hygienic indoor environment through Living Lab piloting. In addition, the project focuses strongly on the support processes required for the successful commercialisation of new innovations from the outset as well as on the commercialisation itself, as it has mostly proven to be challenging also with regard to the new innovations generated by the projects. As a result, the Satakunta region’s R & D activities in the fields of indoor hygiene and related resource efficient building technology will increase, creating new RDI jobs and increasing the amount of private R & D funding. Companies have been very interested in the HygLi project, which points to the attractiveness of the new industry and its recognition as a new innovation opportunity. Companies see indoor hygiene and the associated resource-efficient building technology as an opportunity to renew their own business. The short-term impacts of the project will affect the companies involved in the project, the Living Lab properties as pilot sites, and Satakunta and the whole of Finland, whose business potential in the field will be identified during the project. The long-term impact of the project will affect the entire building services sector through new planning guidelines and resource-wise building engineering solutions, which will also have a positive impact on the education and the environment of the sector by increasing sustainable development solutions. In addition, the long-term impact of the project will be on the Satakunta region by strengthening the region’s smart specialisation in the area of indoor hygiene and related resource-wise building technology, by improving the regeneration capacity of the province’s industry and the renewal of value networks, and by increasing the R & D activities of enterprises in the region with research networks formed by universities, universities and the public sector. The project will increase the conditions for new market openings in the industry and thus for companies to grow nationally and internationally.