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project info
Start date: 1 October 2017
End date: 30 March 2021
funding
Fund: European Regional Development Fund (ERDF)
Total budget: 90 502,00 €
EU contribution: 45 251,00 € (50%)
programme
Programming period: 2014-2021
Managing authority: Conseil régional Nord Pas de Calais

2017 Research Allowances: Reactivation of dormant macrophages in tumours via inhibition of proprotein convertase PC1/3 coupled with the use of LLR receptor ligands (Macbeth)

The project focuses on the development of a therapeutic strategy to reactivate macrophages within tumours. The immunosuppressive environment created by the tumor will direct macrophages towards a pro-tumoral phenotype. They will then participate in the growth of the tumour by acting directly on cancer cells but also by suppressing cytotoxic responses of T lymphocytes, so they are a key element of the tumour environment. The challenge is to find a way to counteract this immunosuppression and reactivate macrophages. The strategy is to use a proprotein convertase inhibitor in combination with a TLR receptor ligand to reactivate tumor macrophages within gliomes.

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