The Human Adaptibility In-Situ (HAIS) project is to measure the ability of humans to adapt physiologically by immersion in different extreme environments for applications and benefits to the general public, sports, scientists, biotechnological and medical. This project proposes two in-situ protocols in which physiological and chronobiological parameters will be studied under two different conditions, one to assess the impact of climate and ultra-endurance and the second to assess the impact of ultra-endurance on human performance:1. The Adaptation Project 4x30 Days2. The Ultra Trail Sciences Project Clécy — Switzerland Normande (UTSPC).Changes and Adaptations are the key words of the present century. Whether we want it or not, whether we accept it or not, our worlds evolve; our lives undergo mutations; our environments are changing. Humans must change their way of life to secure a future on our planet, by reducing pollution, of course, but also by adapting more than ever to their environment, forcing them to surpass themselves. But are we able to do that? What are our resources? How can we develop new skills to react better and faster? To build tomorrow, we need to understand today’s human beings in their environment.The HAIS Project is an original project, never done until then and aims to study the ability of humans to adapt physiologically in extreme real situations, formidable accelerator of Adaptation capabilities.This dossier presents two innovative, original and unique scientific projects in the world. He initiates collaborations between the main teams (UMR INSERM University of Caen COMETE U1075 and the Laboratory of Cognitive and Computational Neurosciences (LNC2) at the Ecole Normale Supérieure in Paris (UMRS INSERM-ENS U960) for the Adaptation 4x30 Jours project which received funding ANR DGA ASTRID 2019, and stimulates collaboration between the members of the COMETE U1075 team and other research teams at national and international level for the UTSPC project. While the Adaptation project carried by the famous explorer Christian CLOT, vice-president of the Société Française des Explorers, an organisation recognised as a public utility, will depart in expedition with 20 people in the 4 most extreme environments on the planet from September 2020, the UTSPC project will organise the first race in the world of ultra-endurance 160 km dedicated to scientific research in Clécy in Switzerland-Normande. These unique projects will value the University of Caen and the Region Normandy by all scientific publications and the organisation of an international conference on Ultra’s practices, which will make it possible to publish the works by the majority of the works, which will be the responsibility of the public sector.