Broncho-Chronopathy Obstructive Chronic Disease (BPCO) is a common respiratory disease associated with a high mortality rate; according to World Health Organisation data, COPD will become the third largest cause of death by 2020. The onset of periods of exacerbation of infectious origin greatly disrupts the quality of life of patients and accelerates the decline in their respiratory function. The management of COPD and these infectious episodes remains complicated in clinical settings and is currently based on unspecific treatments that cannot effectively control the progression of the disease. The primary project aims to develop a new experimental model to better understand the physiopathology of COPD and its exacerbations and to test a new therapeutic strategy.