The overall objective of this R & S Ê is to find solutions to the problem of conventional conventional resistance to treatments. ALTHOUGH THIS IS A GENERAL PROBLEM WITH MANY DIFFERENT TYPES OF CANCER, THE FOCUS OF THIS PROJECT WILL BE FOR BREAST CANCER. THIS OBJECTIVE WILL BE PURSUED THROUGH THE IMPLEMENTATION OF A PROJECT BELL PLATFORM FOR PRE- AND CLINICAL TRIALS AND INNOVATIVE CLINICAL TRIALS FOR ANTI-NEOPLASTIC TREATMENTS. THE PROGRAMME WILL FOCUS PRIMARILY ON THE DEVELOPMENT OF SOME INNOVATIVE THERAPEUTIC APPROACHES (RECOMBINANT VACCINES, MONOCLONAL ANTIBODIES, PEPTIDES AND APTAMERI, SMALL MOLECULES) IN PARALLEL WITH THE IMPLEMENTATION OF WORKING PLATFORMS (CELLULAR AND ANIMAL MODEL SYSTEMS, PERMIT-GRANTING PROCEDURES, BIO-BANKS OF LIQUID BIOPSIES, CONDUCT OF CLINICAL STUDIES OF PHASE I) NECESSARY TO OPTIMISE ACTIVITIES.