The aim of the project is to assess the barrier effectiveness of a new active substance dedicated to use in dermocosmetics against nickel allergy symptoms. According to the WebMD Health Foundation, nickel allergy is the second most common contact allergy, since nickel, as a component of many alloys, is ubiquitous (the objects of everyday use, jewellery, watches, glasses frames, metal elements of clothing, coins, medical and dental tools). Skin changes occur due to skin contact with materials containing this metal – swelling, redness, lump formation and blistering. Nickel allergy suffers from 17 % of women and 3 % of men worldwide. It is most frequently reported among teenagers and certain professional groups (frysers, health professionals, receptionists, cashiers). Despite the introduction of regulation for nickel in products/Directive 94/27/EC/, an increasing proportion of nickel allergy sufferers continue to be observed. In addition, the problem is exacerbated by the lack of treatment and the deficit of protection measures against this allergen. THE SUBJECT OF THE PROJECT IS TO CARRY OUT R+R STUDIES AIMED AT VERIFYING THE EFFECTIVENESS OF THE NEW ACTIVE SUBSTANCE, DEVELOPED BY MODIFYING A BIOCOMPATIBLE POLYMER WITH STRONG NICKEL BINDING CAPABILITIES, DEDICATED TO APPLICATIONS IN DERMOCOSMETICS. The research planned in the project envisages the implementation of the following tasks: I. Efficacy tests of the new active substance against nickel allergy symptoms through in vivo studies in volunteers with confirmed medical examinations of hypersensitivity to nickel.